WEEK 16

Picture what improvement could look like

SEE ACTUAL PSORIASIS PATIENTS TREATED
WITH SKYRIZI (risankizumab-rzaa)2

Photo depicts moderate to severe plaque psoriasis patient with affected body surface area ≥10% at baseline, outside of clinical trials.

CO-PRIMARY ENDPOINTS IN UltIMMA-1 AND UltIMMA-2 (NRI)1,3

PASI 90 at Week 16
UltIMMa-1:
SKYRIZI 75% (229/304), placebo 5% (5/102)
UltIMMa-2:
SKYRIZI 75% (220/294), placebo 2% (2/98)

p<0.0001.

sPGA 0/1 at Week 16
UltIMMa-1:
SKYRIZI 88% (267/304), placebo 8% (8/102)
UltIMMa-2:
SKYRIZI 84% (246/294), placebo 5% (5/98)

NRI=Non-responder imputation.

Study Design:

UltIMMa-1 (N=506) and UltIMMa-2 (N=491) were replicate Phase 3, randomized, double-blind, placebo- and active-controlled studies to evaluate the efficacy and safety of SKYRIZI (150 mg) vs placebo over 16 weeks and biologic active control (45 mg or 90 mg, based on screening weight) over 52 weeks in adult patients with moderate to severe plaque psoriasis. Patients received SKYRIZI 150 mg at Week 0, Week 4, and every 12 weeks thereafter.1,3

VIEW STUDY DESIGN AND BASELINE CHARACTERISTICS

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Meyer Horn.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Illinois

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Insley, RPA-C.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from New York

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Victor Czerkasij, FNP-C.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Tennessee

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Ellen Frankel.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Rhode Island

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Matthew L. Miller2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from South Carolina

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. David Andrew Kasper2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Pennsylvania

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Patient condition before starting SKYRIZI® at Week 0. Week 16 - Drag to view - Image 1
Patient condition before starting SKYRIZI® at Week 0. Week 16 - Drag to view - Image 2
Patient condition before starting SKYRIZI® at Week 0. Week 16 - Drag to view - Image 3
Patient condition before starting SKYRIZI® at Week 0. Week 16 - Drag to view - Image 4
Patient condition before starting SKYRIZI® at Week 0. Image Carousel - Image 5
Patient condition before starting SKYRIZI® at Week 0. Image Carousel - Image 6
Patient condition before starting SKYRIZI® at Week 0. Image Carousel - Image 7
Patient condition before starting SKYRIZI® at Week 0. Image Carousel - Image 8
Patient condition before starting SKYRIZI® at Week 0. Image Carousel - Image 9

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Meyer Horn.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Illinois

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Insley, RPA-C.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from New York

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Victor Czerkasij, FNP-C.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Tennessee

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Ellen Frankel.2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Rhode Island

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Matthew L. Miller2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from South Carolina

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. David Andrew Kasper2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Pennsylvania

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Week 16

Patient results after 2 doses at Week 16

Patient photos representing results captured at baseline and Week 16, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Matthew Bruno, PA-C2

View Week 52 Results
Patient results after 2 doses of SKYRIZI® at Week 16.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 16

Patient from Texas

Patient results after 5 doses SKYRIZI® at Week 52.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 52

Patient from Illinois

Week 52

Patient results after 5 doses at Week 52

Patient photos representing results captured at baseline and Week 52, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Meyer Horn.2

View Week 16 Results
Patient condition before starting SKYRIZI® at Week 0.
Patient results after 5 doses SKYRIZI® at Week 52.
Patient condition before starting SKYRIZI® at Week 0.

BEFORE | WEEK 0

AFTER | WEEK 52

Patient from Illinois

Week 52

Patient results after 5 doses at Week 52

Patient photos representing results captured at baseline and Week 52, outside of clinical trials. PASI and sPGA achievement undefined.2

The patient depicted here has moderate to severe plaque psoriasis with an affected body surface area ≥10%.

Photos courtesy of Dr. Meyer Horn.2

View Week 16 Results

Well-Studied Safety Profile

across 4 pivotal trials1

Review Safety

4 doses per year

3-month dosing after 2 initiation doses at
Weeks 0 and 4 (150 mg/dose)1

View dosing schedule